Macrophage Activation Marker Soluble CD163 Is a Dynamic Marker of Liver Fibrogenesis in Human Immunodeficiency Virus/Hepatitis C Virus Coinfection
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چکیده
منابع مشابه
The hyperferritinemic syndromes and CD163: a marker of macrophage activation.
F erritin is a key protein in iron metabolism. Its involvement in iron detoxification and iron storage is known, but recently, a new role in the pathogenesis of different autoimmune and autoinflammatory syndromes was hypothesized [1]. Four immune mediated conditions sharing the feature of marked hyperferritinemia have been gathered under the single term “Hyperferritinemic Syndromes” [1]. Such s...
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OBJECTIVES To investigate the expression of the soluble form of the resident macrophage marker CD163 (sCD163) and its association with core parameters for disease activity, including radiographic progression in early rheumatoid arthritis (RA). METHODS In a longitudinal sample set from early RA patients (n=34) we measured plasma levels of sCD163 at initiation of treatment and after 9 months of...
متن کاملAlkaline Phosphatase in Serum is a Marker of Human Toxocariasis
Background: The present study was carried out on the human population of Kashmir valley to evaluate the status of the biochemical parameters of infected population. Materials and Methods: Blood samples were collected from 514 individuals, 298 (57.97%) males and 216 (42.02%) females, 187 (36.38%) were found sero-positive for human toxocariasis. Results: Alkaline phosphatase level was found highe...
متن کاملSerum levels of soluble CD163 as a specific marker of macrophage/monocyte activity in sarcoidosis patients.
BACKGROUND Monocyte-macrophage lineage cells are the main immunocompetent cells in sarcoidosis. The main cellular elements of sarcoidal granulomas are epithelioid cells and multinucleated giant cells (MGC). MGC are also produced in vitro by human blood monocytes following various stimuli. The in vitro formation of MGC is a useful tool for understanding granulomas. CD163, a scavenger receptor fo...
متن کاملSoluble CD163 as a Marker of Macrophage Activity in Newly Diagnosed Patients with Multiple Sclerosis
BACKGROUND Soluble CD163 (sCD163) is a macrophage specific protein known to be up-regulated in serum from patients with multiple sclerosis (MS). OBJECTIVE To investigate sCD163 in serum and CSF (cerebrospinal fluid) from patients undergoing MS diagnostic work-up and analyse its potential as a diagnostic biomarker. METHODS After a full MS diagnostic work-up, including collection of paired sa...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2018
ISSN: 0022-1899,1537-6613
DOI: 10.1093/infdis/jiy331